Professional profile
Dr O’Kane works as a high volume Percutaneous Coronary Intervention (PCI) operator performing over 400 cases per year (over 3 times the national average number of PCI). He utilises specialized techniques & equipment not readily available in every UK intervention centre including Rotational atherectomy for otherwise untreatable calcified lesions and Laser PCI to treat highly complex disease.
Dr O’Kane uses pressure wire (PW) and intravascular ultrasound (IVUS) in 30% of all PCI to guide therapy and optimize stent deployment since this improves long term outcome as demonstrated in large clinical studies. His uptake of this technology has been far greater than that seen Nationally where only 7% PCI uses PW & 3.5% IVUS. He also uses optical coherence tomography (OCT) which is the latest tool for imaging coronary arteries and optimizing treatment.
Dr O’Kane readily accepts new challenges and technological advances if they provide an advantage to his patients. He now perform 69% of all PCI cases using radial artery access which has increased from 5% in 2007. Radial access permits a high volume of day case elective PCI providing improved patient outcome and satisfaction. In addition, the vascular access site complication rate is 50% less with transradial PCI in contrast to transfemoral cases.
Dr O’Kane is a European Proctor for laser training and with a colleague has developed regular Coronary Laser workshops to train Consultant Cardiologists from UK and Europe in this evolving technique. The Royal Bournemouth Hospital is the only European centre offering such training.
Clinical Excellence Award
Local: Level 3
Professional affiliations and memberships
- Royal College of Physicians
- British Cardiovascular Society
- British Cardiovascular Intervention Society
- British Medical Association
Research interests
Dr O'Kane was awarded MD in 2005 through University of London for thesis entitled ‘The role of nitric oxide in ischaemic heart disease’.
He subsequently published 4 original scientific papers relating to nitric oxide and the effects of aspirin on platelet nitric oxide synthase and presented abstracts at national & international meetings in London, Paris, Washington, Stockholm, Prague, Atlanta and Sydney.
Dr O'Kane published on the link between coronary heart disease and erectile dysfunction which has been cited over 80 times in the international press.
He has continued to publish as senior author and recently was invited to write a Chapter in the prestigious Oxford Textbook of Interventional Cardiology on Laser PCI.
Dr O'Kane is a local Principal Investigator for international clinical studies including XIMA, BCIS-1 and DAPT. He has also developed an original study investigating the relationship of coronary plaque compostition with functional assessment by pressure wire.
Summary of recent publications
Text Books
- Author(s): O’Kane P & Redwood S, Title: Oxford Textbook of Interventional Cardiology. Redwood, Curzen & Thomas (Eds) - Laser for PCI, Chapter: 13, Year: 2010, Publisher: Oxford University Press, Oxford, UK
- Author(s): O'Kane P & Jackson G, Title: Clinical General Practice - M Selby (ed) - Atrial Fibrillation, Chapter: 9, Year: 2004, Publisher: Butterworth Heinemann, Edinburgh
- Author(s): O'Kane P & Jackson G. , Title: Cardiology: Current Perspectives - Cardiovascular Disease in the Elderly, Chapter: 13, Year: 2002, Publisher: Martin Dunitz, London
Journals
- Author(s): O’Kane P, Reebye V, Yong J, Stratton P, Jackson G, Ferro A, Title: Aspirin and clopidogrel treatment impair nitric ox, Journal: Journal Molecular & Cellular Cardiology , Volume: 45, Year: 2007, PageNo: 223-229
- Author(s): O'Kane P, Jackson G & Ferro A., Title: Whole body nitric oxide production is not decrease, Journal: Atherosclerosis, Volume: 196, Year: 2007, PageNo: 574-579
- Author(s): O'Kane P, Blows L, & Redwood S, Title: New Devices Illustrated: The Venture Wire Control , Journal: The British Journal of Cardiology , Volume: 14, Year: 2007, PageNo: 293-295
- Author(s): O'Kane P, Queen L, Stratton P, Jackson G & Ferro A., Title: Divergent effects of aspirin on basal and b-adreno, Journal: Cardiovascular Research , Volume: 59, Year: 2003, PageNo: 152-159
- Author(s): McKenzie D, Talwar S, Jokhi P, O’Kane P, Title: How should I treat severe coronary artery calcification when it is not possible to dilate a balloon or deliver a RotaWire™?, Journal: Eurointervention, Volume: 6, Year: 2011, PageNo: 779-783
- Author(s): Fernandez JP, Hobson AR, McKenzie D, Talwar S, O’Kane P, Title: Treatment of calcific coronary stenosis with the use of excimer laser coronary atherectomy and rotational atherectomy, Journal: Interventional Cardiology, Volume: 2, Year: 2010, PageNo: 801-806
- Author(s): Jokhi P & O’Kane P, Title: Induction of mechanical and ST-T alternans following angioplasty in severe heart failure, Journal: Eurointervention, Volume: 6, Year: 2010, PageNo: 171
- Author(s): Jokhi PP, McKenzie D, O’Kane P, Title: Use of a novel pericardial covered stent to seal an iatrogenic perforation, Journal: Journal of Invasive Cardiology , Volume: 21, Year: 2009, PageNo: E187-90
- Author(s): O'Kane P, Xie L, Liu Z, Queen L, Jackson G, Yong J & Ferro A. , Title: Aspirin acetylates nitric oxide synthase type 3 in platelets thereby increasing its activity, Journal: Cardiovascular Research, Volume: 83, Year: 2009, PageNo: 131-139
- Author(s): Lockie T, Perera D, O'Kane P, Hartley S, Khan S, Webb I, Redwood S, Title: Deferral of coronary intervention on the basis of fractional flow reserve measurement: a real-world analysis, Journal: Cardiovascular Revascularization Medicine , Volume: 9, Year: 2008, PageNo: 199-200
- Author(s): Jokhi P, Talwar S, O’Kane P, Title: Use of laser atherectomy and IVUS guidance during PCI on a saphenous vein bypass graft with subacute total occlusion, Journal: Eurointervention, Volume: 4, Year: 2008, PageNo: W2
- Author(s): O'Kane P & Jackson G, Title: Erectile dysfunction: Is there underlying obstructive coronary artery disease? , Journal: International Journal of Clinical Practice , Volume: 55, Year: 2001, PageNo: 219-220
- Author(s): O'Kane P & Jackson G, Title: Biochemical Assays in Acute Coronary Syndrome , Journal: Emirates Medical Journal , Volume: 18, Year: 2000, PageNo: 173-176
- Author(s): O'Kane P & Jackson G, Title: Atrial Fibrillation: an update , Journal: Update, Volume: 2, Year: 2000, PageNo: 241249
- Author(s): O'Kane P & Jackson G, Title: ESC Meeting Report - Sexual Activity and the Cardiac Patient, Journal: Sexual Dysfunction in Medicine , Volume: 1, Year: 2000, PageNo: 92-94
- Author(s): O'Kane P & Jackson G. , Title: Cardiovascular Disease in the Elderly, Journal: Practitioner, Volume: 243, Year: 1999, PageNo: 574-580
Other
- Other: Worked as a BCIS-1 Investigator for the following publication:
Perera D, Stables R, Thomas M, Booth J, Pitt M, Blackman D, de Belder A, Redwood S for the BCIS-1 Investigators
Elective intra-aortic balloon counterpulsation during high-risk percutaneous coronary intervention
JAMA 2010; 304(8) 867-874
Web links
Professional Pictures
Click on an image for a description.
Right coronary artery with severe calcifed stenosis causing angina
Right coronary artery after rotational atherectomy and stenting
Intravascular ultrasound (IVUS) showing a previously underdeployed stent in a coronary artery
Optical coherence tomography (OCT) showing a well deployed stent in a coronary artery
Personal profile
Peter O’Kane qualified from Charing Cross & Westminster Medical School in 1995 with certificates of merit in Medicine and Pathology and a first class honours degree in Physiology. After gaining MRCP in 1998 he subsequently trained in General (Internal) Medicine and Cardiology in London at St Thomas’ and St Georges’ Hospitals. His principal subspecialty interest is in interventional cardiology and he was privileged to spend two years in a training fellowship with one of the UK’s leading interventionists, Dr Simon Redwood at St Thomas‘ Hospital. During this period he became skilled in all aspects of coronary intervention including rotational and laser atherectomy, intravascular ultrasound and pressure wire technology. Peter was appointed as Consultant Interventional Cardiologist at the Royal Bournemouth Hospital in July 2007 where he has joined a successful and active unit which has become the UK ‘s highest volume non-surgical PCI centre. He has a longstanding interest in research including his MD into the role of nitric oxide in coronary heart disease working with Professor Ferro at Kings College London, through to ongoing participation in multi-centre randomised clinical trials. He has published numerous scientific papers and articles in peer-reviewed medical journals in addition to book chapters. He has also presented his work at national and international meetings.
Peter’s wife is a Consultant Anaesthetist at The Royal Bournemouth Hospital and they have three young children. He is an enthusiastic cyclist and enjoys spending time with his family.
Personal pictures
Click on an image for a description.
Volumes
- Percutaneous Coronary Intervention - 866 (January 2009 - January 2011)
Audit / Outcomes
Outcomes routinely recorded:
Patient assessed outcome measures
Mortality
